Deficiency of Myeloperoxidase Increases Infarct Volume and Nitrotyrosine Formation in Mouse Brain
نویسندگان
چکیده
منابع مشابه
Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain.
Peroxynitrite is responsible for nitration in vivo, whereas myeloperoxidase can also catalyze protein nitration in the presence of high NO2(-) levels. Recent reports of myeloperoxidase-mediated enzyme inactivation or lipid peroxidation have suggested a role of myeloperoxidase in various pathological conditions. To clarify the role of myeloperoxidase in ischemic brain injury, the authors measure...
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Brain multi-infarct and decompression sickness
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Endothelial Function in a Mouse Model of Myeloperoxidase Deficiency
Myeloperoxidase (MPO) activity is suggested to reduce the function of vascular nitric oxide, thereby contributing to endothelial dysfunction, although data in rodents are inconclusive. We examined vascular contractile and relaxant responses in MPO-deficient (MPO(-/-)) and wild-type mice to investigate the role for myeloperoxidase in the development of endothelial dysfunction. Carotid and saphen...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2002
ISSN: 0271-678X,1559-7016
DOI: 10.1097/00004647-200201000-00006